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Methods: A randomized, double-blind clinical trial was conducted across three centers in Pakistan from April to July 2024

In a head-to-head trial against a full-strength GLP-1 drug, tirzepatide reduced food craving without changing measured restraint. Slower stomach emptying also makes smaller portions feel filling for longer. People whose eating was driven by stress, reward, or constant mental effort often describe the quiet as relief

[4] NNMT is over-expressed in the white adipose tissue and liver of obese, diabetic animals