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While these studies provided evidence for a paradigm shift in the role of JNK in APAP hepatotoxicity, there are some reservations that need to be further explored before discarding a role for JNK in APAP-induced liver injury

Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, et al

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Next, we generated GSSH by reaction of GSH with 03 eqvs