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Angeli JPF, Freitas FP, Nepachalovich P, Puentes L, Zilka O, Inague A

[1] [2] Marketed under brand names including Ozempic, Wegovy, and Rybelsus, semaglutide works by mimicking the action of the naturally occurring hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety

This reduction in heat-generating capacity and insulation leads to increased cold sensitivity, particularly in the extremities

Semaglutide and research subjects Receiving Hemodialysis: Case Reports of Unexpected [PMID: 38720915] Laboratory literature summary: Semaglutide and research subjects Receiving Hemodialysis: Case Reports of Unexpected Benefits for Hyperphosphatemia and Hyperkalemia

20, 2026 JAMA, Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity, Jan