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Furthermore, we calculated the R2 and F statistics to evaluate the strength of instrumental variables, and SNPs with F statistics below 10 were excluded to avoid weak instrumental effects (Supplementary Table 2)

The most common side effects include nausea, diarrhea, constipation, and fatigue, especially in the first few weeks of treatment

Therefore, analyzing the pathogenesis of diseases at the genetic level and developing a personalized treatment plan may offer the possibility of a permanent cure for rare and currently incurable genetic diseases

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