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LONP1 in human diseases As a central regulator of mitochondrial PQC, LONP1 dysregulation contributes to the pathogenesis of diverse human diseases, including neurological, cardiovascular, pulmonary, digestive, renal, reproductive, and musculoskeletal system disorders, and malignant tumors (Fig

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However, despite advances in delivery systems such as lipid nanoparticles, polymers, viral/bacterial vectors, and exosomes, the efficiency of RNA-based therapeutics to specific organs or cell types is limited [81]

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