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These changes (somatopause) are associated with loss of vitality, muscle mass, physical function, together with the occurrence of frailty, central adiposity, cardiovascular complications, and deterioration of mental function

Selenium is required for the function of 25 enzymes, but importantly for vitamin B2 activation Selenium is required for the enzyme Iodothyronine deiodinase, which converts thyroid hormone (T4) to T3

et al., 2017), and silencing lncRNA Neat1 contributes to an increase of GST (Wang et al., 2018)