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Weight Loss Efficacy# Head-to-Head: STEP 8 Trial# The STEP 8 trial (Rubino et al., JAMA 2022) directly compared semaglutide 2.4 mg weekly to liraglutide 3.0 mg daily in 338 adults with overweight or obesity without diabetes over 68 weeks

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Effectiveness also depends on effective absorption of the medication, and the pill must be taken in a specific way to make sure it is absorbed properly. The Rybelsus pill reduced A1C slightly less than the Ozempic injection, by about 1.0 % to 1.3 % from baseline over 26 weeks