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This temporary nature is actually a safety feature, ensuring that any changes aren't irreversible
when refolding fails, it helps direct these proteins toward degradation pathways (Rosenzweig et al., 2019)
The safety record supports it
For example, Sermorelin half-life values in the literature range from 11 minutes to 20 minutes depending on whether the assay used radioimmunological detection or HPLC-MS, and whether the species was rat, dog, or human
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