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lappa , is an orally administered drug rich in arctigenin that showed high arcitgenin bioavailability, while arctiin was not detected in the pharmacokinetic profile [82]

However, approximately6% of HIV-positive persons fail to develop HCV antibodies, and therefore HCV RNA should be tested in HIV-positive persons with unexplained liver disease who are anti-HCV negative103, 104

Smaller, more frequent doses keep peak plasma concentrations flatter, which is what drives most of the side-effect burden

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