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At the second screening visit the site determines whether the subject was eligible, then completed a randomization request form that was faxed to one of the authors (CS) who would assign the subject per the predetermined randomization list

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Male C57BL/6 mice, aged 810 weeks and weighing between 20-28 g, were housed under controlled conditions (22C 2C, 12-hour light/dark cycle) and provided with ad libitum access to food and water

Importantly, these data did not originate from randomized colorectal cancer prevention trials

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