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Amide linkages are characterised by partial double-bond character due to resonance stabilisation between carbonyl and nitrogen atoms

In another study mice treated with low-dose penicillin in early life, however, have increased mRNA and protein expression of tight junction proteins in the hippocampus [149]

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Furthermore, it may alter the transcript levels of genes involved in oogenesis, folliculogenesis, and embryonic development 12 and impair nuclear and cytoplasmic maturation events such as the translocation of cortical granules and cytoskeletal rearrangement 13 , which can eventually lead to apoptosis 14