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doi: 10.1021/acs.est.5b04111 77 MacDonaldM
In the TgAPP/PS1 mouse model, azeliragon curtails the deposition of amyloidbeta (A) oligomers by impeding the binding of A to RAGE
The GutBrainMitochondria Axis in Autism The process can be understood as a biological cascade: Gut dysbiosis imbalance in the microbiome Leaky gut increased intestinal permeability Microbial metabolites enter the bloodstream Neuroinflammation and oxidative stress occur in the brain Mitochondrial dysfunction affects neuronal development This interconnected system helps explain why many children with ASD experience gastrointestinal symptoms, immune irregularities, and metabolic differences alongside neurological symptoms
Extracellular vesicles-based cell-cell communication in melanoma: new perspectives in diagnostics and therapy
The preclinical data support a biological mechanism relevant to this injury type
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