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The high diagnostic value of SN hyperechogenicity in differentiating PD from other movement disorders such as multiple system atrophy, essential tremor, and progressive supranuclear palsy, as well as the auxiliary role of lenticular hyperechoic area in differential diagnosis, suggest that transcranial sonography can serve as an effective discriminant index for PD diagnosis (221)

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Animal research, including a study in aged rhesus monkeys, found that Epitalon administration significantly stimulated evening melatonin synthesis in older animals, normalizing a circadian rhythm that typically deteriorates with age