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What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology
In these studies, researchers evaluate whether BPC-157 or GHK-Cu causes DNA damage or has the potential to promote cancerous growth
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B12/MIC also helps improve liver function and overall metabolism, both of which go a long way towards our longevity
Many insurances may still require a failure of at least 2 categories of standard preventive medications before they will approve Botox coverage, but these requirements are starting to loosen up
