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7 Compared with placebo, patients taking metformin had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years)
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Another study reported that the bitter taste of berberine causes the activation of bitter taste receptors (TAS2Rs), which further activates the downstream signalling pathway, leading to enhanced GLP-1 secretion 4
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