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308 Rather than harboring stable resistance mutations, DTP cells adopt a slow-cycling or quasiquiescent phenotype driven by extensive epigenetic remodeling, transcriptional plasticity and metabolic reprogramming, which collectively constitute core maintenance programs that stabilize the DTP state under therapeutic pressure
The rate of loss slowed somewhat in the later weeks as a new energy balance was approached, but the trajectory had not leveled off by week 48
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They work by imitating the natural hormones effect on the body
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