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One major issue is high target heterogeneity
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Previous work on the crucial role of SOX2 in breast cancer cell migration showed that SOX2 upregulation in hypoxic conditions facilitated NEDD9 transcription and subsequent activation of HIF-1 expression 62
Firstly, bacteria have good tumor colonization ability and can accumulate at the lesion site
Ethics approval and consent to participate This study was approved by the Ethics Committee of Jiangxi Provincial Peoples Hospital (protocol code KT078), and the maximal tumor size permitted is 150 mm
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