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This suggests that a gradual dose increase may be beneficial in managing these adverse events

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Thus, truncation of the C-terminal L585 residue of the GLP-1 fusion containing WT albumin reduces its cellular recycling in vitro and plasma half-life in vivo, which may be compensated for by QMP engineering of albumin, irrespective of the presence of L585

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Vivoli E et al

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doi:10.1111/j.1476-5381.1990.tb12998.x

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