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Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)

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To verify this hypothesis, we upregulated the expression of VRK2 in PC cells (PANC-1 cells and BxPC-3 cells) and examine the expression of SLC7A11 at whole cell and PM levels

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