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Patients should be counseled to check the beyond-use date before each use and to properly dispose of any remaining medication after this date
Discontinuation may be warranted if allergic reactions occur, if side effects persist despite slower dosing, or if baseline conditions (acute kidney injury, active infection) change
Besides, GLP-1RAs might be driven by anti-inflammatory mechanisms to inhibit the formation of macrophage foam cells and thus slow down the pathological processes of AS (125, 126)
In PD models, no studies to date have explored the potential of irisin to modulate lactate metabolism within dopaminergic neurons
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