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Nanocarriers overcoming biological barriers induced by multidrug resistance of chemotherapeutics in 2D and 3D cancer models

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20 min LH, due to hyperglycosylation) Mechanisms of Action: LH/hCG Receptor Activation (LHCGR): Receptor: GPCR (7-transmembrane) in testicular Leydig cells, ovarian theca Translation: Gs protein coupling adenylate cyclase cAMP PKA Cascade: StAR (steroidogenic acute regulatory protein) phosphorylation Result: Mitochondrial cholesterol transport steroidogenesis Testicular Steroidogenesis: Leydig cells: testosterone synthesis stimulation Key enzymes: CYP11A1 (side-chain cleavage), 3-HSD, 17-HSD Testosterone production: 200400% increase in baseline levels Paracrine effects: spermatogenesis support (Sertoli cells) Ovarian Function Preovulatory follicle: final maturation, ovulation Corpus luteum: maintenance of progesterone production Luteinization: granulosa/theca cell differentiation Angiogenesis: luteal body vascularization (VEGF pathway) Recombinant hCG Pharmacokinetics: SC bioavailability: 4050% (vs

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These results supported the hypothesis that ACTL6A impacts GSH de novo synthesis mainly by regulating GCLC expression