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In this review the family is analyzed as well as their cardiovascular and renal effects La enfermedad renal diabtica, frecuente en pacientes con diabetes mellitus tipo 2, se asocia con un marcado incremento de la morbimortalidad, especialmente cardiovascular, y de progresin a enfermedad renal crnica terminal

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Each step roughly doubles the dose, placing significant new demands on the body systems affected by GLP-1 receptor activation