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"People who have alcohol use disorder get an internal brain reward for drinking, and we think that the semaglutide removes at least part of that sense of being rewarded for taking a drink." Though the research is promising, Xu said it's merely an observational study from clinical trials, meaning more research is needed before her team makes any recommendations for prescribing semaglutide for substance use treatment
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If this line of thinking is applied to the mesolimbic GLP-1R activation, it is plausible that while NAc GLP-1R activation is associated with a suppression of the dopamine signal, the VTA GLP-1R reduce reward behavior via another mechanism
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