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These include tissue repair, inflammation control and blood vessel formation
Effective design requires matching the pH activation window to the extent of joint acidification, tuning release timing through crosslink strength and diffusion channels, and enhancing cartilage affinity or cellular uptake to limit unproductive diffusion while improving deep penetration and repair efficiency
Melanotan-2 is the parent analog with non-selective pan-melanocortin activity
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doi: 10.1016/S0140-6736(12)61031-9 275 AlbalakGStijntjesMVan BodegomDJukemaJWAtsmaDEVan HeemstDet al
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