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Graziano MP, Hey PJ, Borkowski D, Chicchi GG, and Strader CD

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Clinical studies show that patients typically lose an average of 5 to 7 pounds (about 2 to 3 kilograms) in the first month at the starting dose

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An easier-to-take oral GLP-1 (orforglipron) is in development

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Various mechanisms have been theorized to describe how dual agonism, as GLP-1 RA, could directly reduce triglycerides hepatocyte storage, lipogenesis and improving hepatic glucose metabolism (96) and promoting lipolysis and fatty acid oxidation (97)

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