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doi: 10.1371/journal.pone.0010185 41 TuttleKR
The skin is the largest organ in the human body, comprising up to 16 percent of total body weight (83)
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A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation
There also is a tangled web of medical and social factors surrounding obesity, all of which are shadowed by persistent stigma around weight
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