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The excess ROS, including superoxide anion (O 2 ), singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and so on, would induce oxidative damage to biomolecules (e.g., proteins, lipids, and DNA) and, thus, lead to severe cellular damage ( 2 (Rothenberg et al., 2003), CP of 350 mg/m 2 ( To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Lim et al., 2010

Hoyes KP, Morris ID, Hendry JH, Sharma HL