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K-means clustering of amplicon sequence variant data confirmed that 5-Amino-1MQ treatment generated a distinct cecal microbiome profile from all other treatment groups including diet-switched vehicle controls indicating that NNMT inhibition produces microbiome changes that are separable from those produced by dietary composition alone

Increase insulin production Reduces food intake by lowering appetite Slows food digestion in the stomach Weight loss Improved cardiometabolic measures A1C Production

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Kaluza J, Larsson SC, Orsini N, Linden A, Wolk A