Key possibilities include: Deferring action: The FDA could put off any action on the peptides at issue
The Preclinical Evaluation of TIC10/ONC201 as an Anti-pancreatic Cancer Agent
It effectively stimulates GH release but it also raises cortisol (stress hormone), prolactin (reproductive hormone), and aldosterone (blood pressure regulator), and produces intense hunger (ghrelin-like appetite stimulation). For researchers, these off-target effects create experimental noise
Patients consuming significantly fewer calories may not meet requirements for essential micronutrients, including B vitamins, iron, and vitamin D, all of which play crucial roles in energy metabolism
It also slows down gastric emptying (so you feel fuller for longer) and sends signals to the brain to tell the body its full which helps suppress appetite and prevent overeating (Solan, 2023)