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Access this article Similar content being viewed by others Abbreviations A-42: Beta amyloid-(1-42) is a major component of cerebrovascular amyloid deposits AKT, PKB: Protein kinase B, commonly referred to as Akt AP-1: Activated protein-1 APC: Anaphase promoting complex ATR: Ataxia telangiectasia and Rad3-related protein A: Amyloid-beta AYUSH: Ayurveda, Yoga, Unani, Siddha, Homeopathy BCL-2: B-cell lymphoma-2, a gene belonging to the group of Bcl family BCL-XL: A Bcl gene variant BDNF: Brain development neurotrophic factor, a key in learning and memory BT: Body temperature CDC 2: Cell division cycle 2 CDC 20: Cell division cycle 20 CDK: Cyclin-dependent kinases C-JUN: A protein encoded by the JUN gene, an early transcription factor COX-2: Cyclooxygenase-2 DB: Double-blind DR-4, 6: Death receptor IL: Interleukin is a type of cytokine IFN-: Interferon gamma MAPK/ERK: Also known as Ras-Raf-MEK-ERK pathway MMP-1: Matrix metalloproteinase-1 MTOR: Mammalian target of rapamycin, a central regulator NF-B: Nuclear factor-kappa B is n inducible transcription factor P21: Cyclin-dependent kinase inhibitor, primarily inhibiting CDK2 and CDK1 P53: Tumor protein- p53 PC: Placebo control R: Randomized RDRP: RNA-dependent RNA polymerase PPAR-: Peroxisome proliferator-activated receptors STAT 3: Signal transducer and activator of transcription 3 TH-1: T helper type-1 plays a specific role in immune response TNF-: Tumour necrosis factor WNT: Wingless-related integration site References Ahmad, R.S., Hussain, M.B., Sultan, M.B., Sajid, M.B., Waheed, M., Shariati, M.A., Plygun, S., Hashempur, M.H.: Biochemistry, safety, pharmacological activities and clinical applications of turmeric: a mechanistic review

Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump