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however, these biochemical markers were improved significantly in the second study

Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study

Amit Gupta for highlighting this important study

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Surprisingly, metformin prolonged the lifespan of mammals and decreased lung inflammation caused by COVID-19 in a mouse model of acute respiratory distress, possibly by blocking the activation of NLRP3 inflammasome through the inhibition of mitochondrial DNA synthesis (Xian et al., 2021)