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Contrariwise, other relevant aspects, such as the safety profile and tolerability of GLP-1RA or the beneficial effects on fertility in PCOS, have been more extensively treated, especially considering that possible direct or indirect reproductive effects of GLP-1 RA might require a concomitant effective contraception and a washout period before pregnancy [22, 24,25,26,27,28,29,30,31]
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This means that patients often find a better balance between energy intake and output, rather than their previous higher caloric intake and lower energy output
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