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J Biol Chem (1987) 262:897580
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This effect is attributed to PCs dose-dependently enhancing GSK-3 phosphorylation, attenuating caspase-3 activation, and inhibiting lactic acid adhesion protein expression, thereby mitigating oxidative stress and apoptosis induced by AGEs in HUVECs
Methods: ELISA assays measuring the matricellular fibrosis marker thrombospondin-2 (TSP2) and the metabolism/fibrosis-related marker insulin-like growth factor binding protein-7 (IGFBP7) were established using combinations of recombinantly expressed protein, commercial and proprietary monoclonal/polyclonal antibodies
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