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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) present an important new treatment option for patients with obesity, and act primarily by decreasing caloric intake through appetite suppression
Common side effects of GLP-1 medications The most commonly reported side effects associated with GLP-1 receptor agonists in clinical literature include nausea, vomiting, diarrhea, constipation, and abdominal discomfort
Retatrutide activates GLP-1, GIP, and glucagon receptors in one molecule, distinguishing it from single agonists like semaglutide and dual agonists like tirzepatide
