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The metabolites are excreted in the urine, allowing it to exert local effects on the bladder

ATD have always been the treatment of choice for uncomplicated cases in Europe and Japan, but RAI was the favourite treatment modality in the USA

Both glutamate uptake by astrocytes and its mitochondrial catabolism initiated by glutamate dehydrogenase are important nodes of glutamatergic regulation within astrocytes, and alterations of these processes might contribute to metabolic deregulation in schizophrenia

Its antioxidant capacity has been demonstrated to be up to 6,000 times more potent than vitamin C and up to 100 times more effective than vitamin E 1

Some protocols use two-week escalation intervals with higher starting doses