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Prieto J, Qian C, Garcia N, Diez J, Medina JF
Objective biomarkers (telomere length, immune markers, melatonin levels) require specialized testing and may not show clear changes
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Deeper concerns like pigmentation and fine lines take eight to twelve weeks of consistent use to show significant change
Because clearance is slow, an intolerable dose cannot be reversed quickly discontinuation does not produce prompt washout
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