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For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

Intellectual property implications The semaglutide case highlights the ongoing debate between patent protection for innovation and broader access to medicines

Unlike other diabetes therapies, GLP-1 receptor demonstrates enhanced efficacy in reducing HbA1c levels and body weight

In the U.S., concentrations of 4% or higher are available as a prescription or compounded to treat stubborn pigment conditions like melasma, says Dr

10.2114/jpa.16.257 289 VaishyaR.MisraA.VaishA.UrsinoN.DAmbrosiR