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A deficiency in vitamin B12 has been linked to depression and other mood disorders
Mechanistic validation further confirmed downregulated expression of Nrf2, HO-1, and GPX4 in CLP mice, establishing a direct link between glutathione dysregulation and neuronal apoptosis
More severe protein damage can lead to greater HSF1 release and a stronger subsequent heat shock response
This constitutes a potential mechanism of bone marrow suppression observed in patients undergoing chemotherapy [68]
In addition, loss of glutathione peroxidase 4 (GPX4), a central regulator of ferroptosis, leads to hemolytic anemia and increases spleen erythroid progenitor death through receptor-interacting protein 3 (RIP3)-dependent necroptosis signaling 48
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