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The practice comes from observations that continuous peptide use may reduce effectiveness over time and that breaks allow receptor sensitivity to reset

Important Warnings BPC-157 has not been approved for human use by any regulatory agency

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Endpoints: wound closure rate (planimetry, ImageJ), granulation tissue (histological scoring), collagen organization (Picrosirius red), re-epithelialization (H&E), tensile strength (mechanical testing)

Native amylin readily forms amyloid fibrils protein aggregates that not only render the peptide non-functional but are also implicated in the pancreatic pathology of type 2 diabetes