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3) PPAR Two randomized, double-blind, placebo-controlled trials (RDBPCT) have shown that pioglitazone [peroxisome proliferator-activated receptor gamma (PPAR) agonist] significantly ameliorated steatosis and necroinflammation compared to placebo in diabetic NASH [24, 25]

In some cases, a lower maintenance dose may be chosen if it achieves weight loss with minimal side effects

Liver function: Research has shown that semaglutide results in improved liver fat and scarring, and MASH (which stands for metabolic dysfunction-associated steatohepatitis) is an FDA-approved indication

KPV's anti-inflammatory effects are NOT melanocortin receptor-mediated

CJC-1295 (without DAC) is a synthetic 30-amino-acid analogue of GHRH