Its potential benefit has been posited due to its effect on improving mitochondrial function and the benefit seen as a neuroprotective agent in other clinical situations such as ischemic stroke, neurodegenerative diseases, and chemotherapy-induced encephalopathy.13 The authors of one article posited 2-3mg/kg/day divided into three doses for 7-10 days for newly infected patients could be a reasonable dose for initial studies.14 Given one meta-analysis reported that 12-35% of patients with long COVID suffered from cognitive impairment (colloquially called brain fog) and another found elevated brain injury markers during the acute phase of COVID-19, potential treatment and management strategies are in demand.13,14,15 Currently there are some trials evaluating the use of methylene blue for COVID-19, though, results and outcomes are not yet available.16,17 Brain injury and traumatic brain injury continue to be significant sources of morbidity and mortality and effective treatment options for prevention of acute and long-term damage are needed

Even in people without overt deficiency, B12 injections can correct subclinical insufficiency more rapidly than oral supplementation
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In the trial it meant the two groups finished in a similar place after six months
The peptide accelerates early collagen organization and stimulates expression of the EGR-1 gene along with its repressor NAB2, creating a regulatory feedback loop that prevents excessive fibrosis while promoting organized tissue remodeling