doi: 10.1007/s40123-023-00711-2 146 VasavadaARShahARajSMPraveenMRShahGD
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The absorption of metformin is confined very largely to the small intestine [42, 50, 67], therefore in the model, the small intestine is the only organ where the absorption takes place
[5] [6] Clinical trial data from the SURPASS and SURMOUNT studies demonstrate that gastrointestinal adverse eventsincluding nausea, diarrhea, vomiting, constipation, and abdominal discomfortoccur frequently with tirzepatide