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The organic solvent was evaporated under reduced pressure at 30 C using a rotary evaporator (IKA RV 10, Staufen, Germany) operating at 180 rpm and 380 mbar, producing a viscous organogel

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For example, tirzepatide may reduce the effectiveness of oral contraceptives, and patients taking warfarin with any GLP-1 receptor agonist should consider more frequent INR monitoring when starting or stopping therapy

However, NICE Technology Appraisal 875 restricts NHS use of semaglutide 2.4 mg to specialist weight management services, for people with BMI 35 kg/m with at least one weight-related comorbidity (with specific exceptions for BMI 30-34.9 kg/m), and for a maximum of 2 years

In addition, healthcare record data may not capture all substance use cases