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For the analyses of this estimand, missing values (unobserved due to patient loss to follow-up or other reasons) were assumed to be missing at random and were handled by multiple imputation using observed data in the placebo group

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However, these benefits were based on clinical endpoints and did not include direct measures of renal fibrosis, such as histology or fibrosis-specific biomarkers [55]

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Secondly, the blockage of cystine uptake by the cystine/glutamate antiporter (system Xc , composed of SLC7A11/SLC3A2) leads to reduced GSH synthesis, which in turn inhibits the activity of glutathione peroxidase 4 (GPX4), preventing it from effectively clearing lipid peroxides (l-OOH) [74]