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Impact of GLP-1 and GLP-1 receptor agonists on cardiovascular risk factors in type 2 diabetes
El GLP-1 circulante tiene una vida media muy corta (menos de 2 min) y se inactiva en forma rpida, prin cipalmente por la ubicua enzima proteoltica dipeptidil peptidasa tipo 4 (DPP-4) y, en menor grado, por otras endo y aminopeptidasas 20
doi:10.1016/j.bbr.2009.06.035 143
Weight regain after stopping is a documented pattern with all GLP-1 class compounds, and Retatrutide is expected to follow the same pattern
Mild side effects like temporary redness at the injection site or nasal irritation (for sprays) may occur, but these are rare and manageable
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