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Unlike the Cagri-CTR-Gs complexes, in the CagriBB-bound CTR H296 ECL2 adopted the inward rotamer position that was observed when bound to other non-lipidated peptides, and ECL3 formed the more closed conformation in both experimental repeats

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Acromegalic effects Prolonged elevation of IGF-1 can cause changes similar to acromegaly, the condition caused by excess growth hormone in adults

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