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Both melanogenesis and anti-inflammatory signalling downstream of MC1R activation share the same upstream cAMP-PKA pathway
Energy levels and exercise performance reflect metabolic activity
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Gastrointestinal Side Effects The most common adverse events were gastrointestinal in nature, as expected for this drug class: Nausea the most frequently reported GI side effect, typically most pronounced during dose escalation and diminishing over time Diarrhea reported at moderate frequency Constipation less common than nausea but clinically relevant for some participants Vomiting generally mild and often transient These GI effects are mechanistically linked to GLP-1 receptor activation (slowed gastric emptying, central appetite suppression) and are a recognized feature of all GLP-1-based therapies
95% CI, 0.77 to 0.98), stroke by 18% (HR, 0.82
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