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Risk factors include older age, autonomic neuropathy, polypharmacy (especially antihypertensives and diuretics), and volume depletion from gastrointestinal side effects
Heitmann BL
S., & Nolan, J
Chen J, Qiao K, Zhang C, Zhou X, Du Q, Deng Y, et al
While data specific to GLP-1 RA discontinuation remain limited, a large-scale prospective study on weight cycling (mean age 63.6 years, at high risk of T2DM) reported that weight regain was typically characterized by an adverse shift in body composition, with FM returning to baseline levels while FFM declined by 1.50 kg (95% CI 0.662.35)
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