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Ethics statement The studies involving humans were approved by The Maribor University Medical Centre medical ethics committee(document number UKC-MB-KME-50/24)
Studies have shown that smoking cessation results in a decrease in pigmentation, with prevalence similar to that of nonsmokers, seen in patients who have quit the habit for at least 3 years
After receiving approval from the U.S
For experiments requiring sustained exposure, twice-daily dosing (morning and evening) maintains more stable plasma levels than single daily administration
The remaining 39 subjects completed the trial and all 41 subjects were included in the full and safety analysis sets
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