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Proc Natl Acad Sci 105: 4364-4369
Recovery is never about one intervention
Your prescriber may recommend staying on a current dose longer if: You are experiencing ongoing nausea or vomiting You feel dizzy or fatigued You are losing weight steadily without needing an increase You prefer to remain on a well-tolerated dose Increasing too quickly can reduce adherence and make side effects harder to manage
These multidimensional factors spanning mitochondrial metabolism, cellular aging, metabolic function, and childhood trauma provided more detailed signatures to predict longitudinal changes in depression severity than each individual factor alone
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